With 1000 residents, located east on the island and is 3 km from Ermoupolis.

The first Venetian city was built amphitheatrically on the hills of Saint George, close to the natural port of the island. On its peak stands the Catholic Church also named Saint George, highlighting the medieval atmosphere, an age which left its mark characteristically on the town. These elements are the narrow intricate laneways with many stairways, whitewashed houses with the unusual two part doors, the small gardens, wooden balconies, as well as the indigo flowers that blend the white with the blue sky. Ano Syros is a town without noise or pollution from cars. Due to its narrow roads, cars are unable to access most of it.
A city with strong musical traditions, especially where the folk and the rebetiko style of song are concerned. This musical town produced the preeminent Marko Vamvakari.